Drug Information

Drug General Information
Drug ID
D0V5AN
Former ID
DNC009228
Drug Name
6-tosyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529564]
Structure
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2D MOL

3D MOL
Formula
C19H20N2O2S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2C3=C(CCNCC3)C4=CC=CC=C42
InChI
1S/C19H20N2O2S/c1-14-6-8-15(9-7-14)24(22,23)21-18-5-3-2-4-16(18)17-10-12-20-13-11-19(17)21/h2-9,20H,10-13H2,1H3
InChIKey
LXDIYGJJOWTGAR-UHFFFAOYSA-N
PubChem Compound ID
44567986
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529564]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529564Bioorg Med Chem Lett. 2008 Jul 15;18(14):3929-31. Epub 2008 Jun 13.A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.
Ref 529564Bioorg Med Chem Lett. 2008 Jul 15;18(14):3929-31. Epub 2008 Jun 13.A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.

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