Drug Information

Drug General Information
Drug ID
D0V5YJ
Former ID
DNC003568
Drug Name
Ro-63-0563
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539794]
Formula
C13H17N5O2S
InChI
InChI=1S/C13H17N5O2S/c1-15-12-7-10(8-13(16-2)17-12)18-21(19,20)11-5-3-9(14)4-6-11/h3-8H,14H2,1-2H3,(H3,15,16,17,18)
InChIKey
PTFNKZLSFWJYFJ-UHFFFAOYSA-N
PubChem Compound ID
5312144
PubChem Substance ID
7980530, 11056902, 14825549, 39341762, 52588963, 57359527, 85209266, 103229985, 103988996, 114157990, 128964919, 134340773, 135650921, 140775876, 141679211, 178100295, 226973783
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529191]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539794(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 275).
Ref 529191Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. Epub 2007 Nov 17.Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.

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