| Drug General Information |
| Drug ID |
D0VJ2S
|
| Former ID |
DIB020116
|
| Drug Name |
JNK-IN-8
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C29H29N7O2
|
| InChI |
InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
|
| InChIKey |
GJFCSAPFHAXMSF-UXBLZVDNSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
136352682, 152258536, 160647370, 163332956, 163830877, 164178260, 170474703, 185990488, 226088005, 239943895, 249565738, 252160952, 252554050
|
| Target and Pathway |
| Target(s) |
mRNA of human Jun-N-terminal kinase-2 (JNK2) |
Target Info |
Inhibitor |
[1]
|
|---|
| Mitogen-activated protein kinase 10 |
Target Info |
Inhibitor |
[1]
|
| Mitogen-activated protein kinase 8 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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cAMP signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Protein processing in endoplasmic reticulum
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Wnt signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Hepatitis B
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Influenza A
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Pancreatic cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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HTLV-I infection
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Choline metabolism in cancer
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NetPath Pathway
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IL5 Signaling Pathway
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TNFalpha Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Apoptosis signaling pathway
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B cell activation
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FAS signaling pathway
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Huntington disease
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Integrin signalling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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Parkinson disease
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TGF-beta signaling pathway
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T cell activation
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Toll receptor signaling pathway
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Ras Pathway
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CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
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EGF receptor signaling pathway
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FGF signaling pathway
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Angiogenesis
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PDGF signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Noncanonical Wnt signaling pathway
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CD40/CD40L signaling
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CDC42 signaling events
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FAS (CD95) signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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FoxO family signaling
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p75(NTR)-mediated signaling
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ErbB1 downstream signaling
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ATF-2 transcription factor network
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ErbB2/ErbB3 signaling events
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PDGFR-beta signaling pathway
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Nephrin/Neph1 signaling in the kidney podocyte
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p53 pathway
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Downstream signaling in naï
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RAC1 signaling pathway
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Regulation of retinoblastoma protein
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Signaling events mediated by focal adhesion kinase
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Glypican 3 network
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IL12 signaling mediated by STAT4wnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
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Nephrin/Neph1 signaling in the kidney podocytefcer1pathway:Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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RhoA signaling pathway
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Osteopontin-mediated events
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Reelin signaling pathway
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TRAIL signaling pathway
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Signaling events regulated by Ret tyrosine kinase
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Angiopoietin receptor Tie2-mediated signaling
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IL1-mediated signaling events
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Ceramide signaling pathway
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Regulation of Androgen receptor activity
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JNK signaling in the CD4+ TCR pathway
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Retinoic acid receptors-mediated signaling
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Syndecan-2-mediated signaling events
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Ephrin B reverse signaling
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N-cadherin signaling events
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S1P2 pathway
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IL12 signaling mediated by STAT4
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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Oxidative Stress Induced Senescence
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FCERI mediated MAPK activation
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JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
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Activation of the AP-1 family of transcription factorsR-HSA-2559580:Oxidative Stress Induced Senescence
|
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Activation of the AP-1 family of transcription factorsR-HSA-193648:NRAGE signals death through JNK
|
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NRIF signals cell death from the nucleus
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DSCAM interactions
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Activation of the AP-1 family of transcription factors
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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WikiPathways
|
Toll-like receptor signaling pathway
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DNA Damage Response (only ATM dependent)
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TCR Signaling Pathway
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TGF Beta Signaling Pathway
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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TGF beta Signaling Pathway
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Wnt Signaling Pathway Netpath
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Nanoparticle-mediated activation of receptor signaling
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Structural Pathway of Interleukin 1 (IL-1)
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JAK/STAT
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ATM Signaling Pathway
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BDNF signaling pathway
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Corticotropin-releasing hormone
|
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AGE/RAGE pathway
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TNF alpha Signaling Pathway
|
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B Cell Receptor Signaling Pathway
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
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RANKL/RANK Signaling Pathway
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IL-1 signaling pathway
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Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
|
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G13 Signaling Pathway
|
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MAPK Cascade
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Oxidative Stress
|
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Apoptosis Modulation by HSP70
|
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MAPK Signaling Pathway
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Apoptosis
|
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Integrin-mediated Cell Adhesion
|
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ErbB Signaling Pathway
|
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FAS pathway and Stress induction of HSP regulation
|
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Signaling of Hepatocyte Growth Factor Receptor
|
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Kit receptor signaling pathway
|
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Transcriptional activation by NRF2
|
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NLR Proteins
|
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IL-3 Signaling Pathway
|
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Cardiac Hypertrophic Response
|
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EBV LMP1 signaling
|
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PDGF Pathway
|
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Nanoparticle triggered regulated necrosis
|
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Prostate Cancer
|
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Leptin signaling pathway
|
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Signalling by NGF
|
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Intrinsic Pathway for Apoptosis
|
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DSCAM interactions
|
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Apoptosis Modulation and Signaling
|
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Type II diabetes mellitus
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathway
|
|
Osteoclast Signaling
|
| References |
| REF 1 | Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. |
|---|
