Drug Information

Drug General Information
Drug ID
D0VL3R
Former ID
DNC009633
Drug Name
3-(5,6,7,8-Tetrahydronaphthalen-2-yl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529834]
Structure
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2D MOL

3D MOL
Formula
C15H15N
Canonical SMILES
C1CCC2=C(C1)C=CC(=C2)C3=CN=CC=C3
InChI
1S/C15H15N/c1-2-5-13-10-14(8-7-12(13)4-1)15-6-3-9-16-11-15/h3,6-11H,1-2,4-5H2
InChIKey
WGNJGUOGXBTDMP-UHFFFAOYSA-N
PubChem Compound ID
25180303
Target and Pathway
Target(s) Cytochrome P450 11B1, mitochondrial Target Info Inhibitor [529834]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Mineralocorticoid biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Corticotropin-releasing hormone
References
Ref 529834J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Ref 529834J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

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