Drug Information

Drug General Information
Drug ID
D0VZ3D
Former ID
DIB013326
Drug Name
AQ-RA-741
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Terminated [543206], [545137]
Company
Dr Karl Thomae GmbH
Structure
Download
2D MOL

3D MOL
Formula
C27H37N5O2
InChI
InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)
InChIKey
BCUGCHZRMKTPMU-UHFFFAOYSA-N
CAS Number
CAS 123548-16-3
PubChem Compound ID
129989
PubChem Substance ID
10242493, 12014256, 14907179, 26753266, 29308690, 47510065, 48105189, 57343231, 78254277, 85788187, 91746621, 103223257, 104371738, 126436783, 127496880, 131342474, 135084946, 135698248, 162023254, 162312721, 162781867, 172657834, 179149727, 184538649, 196372351, 204380143, 215779624, 223554803, 224953712, 233158255, 252156418, 252166785, 252325817
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Modulator [533924]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543206(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8584).
Ref 545137Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002261)
Ref 533924Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur J Pharmacol. 1994 Mar 3;253(3):275-81.

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