Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W2ED
|
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| Former ID |
DNC004327
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| Drug Name |
L-731735
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| Drug Type |
Small molecular drug
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C19H40N4O4S
|
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| Canonical SMILES |
CCC(C)C(CNC(C(C)CC)C(=O)NC(CCO)C(=O)O)NCC(CS)N
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| InChI |
1S/C19H40N4O4S/c1-5-12(3)16(21-9-14(20)11-28)10-22-17(13(4)6-2)18(25)23-15(7-8-24)19(26)27/h12-17,21-22,24,28H,5-11,20H2,1-4H3,(H,23,25)(H,26,27)/t12-,13+,14-,15+,16-,17+/m1/s1
|
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| InChIKey |
LMTIEVNRUFAFPM-VRXFMZDNSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Farnesyltransferase | Target Info | Inhibitor | [2] | |
| Protein farnesyltransferase beta subunit | Target Info | Inhibitor | [3] | ||
| KEGG Pathway | Terpenoid backbone biosynthesis | ||||
| Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis | |||||
| Biosynthesis of antibiotics | |||||
| NetPath Pathway | TSH Signaling Pathway | ||||
| Reactome | Apoptotic cleavage of cellular proteins | ||||
| Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade | |||||
| WikiPathways | Visual phototransduction | ||||
| Apoptotic execution phaseWP2776:Visual phototransduction | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002714) | ||||
| REF 2 | J Med Chem. 1998 Jul 2;41(14):2651-6.N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase. | ||||
| REF 3 | J Med Chem. 1997 Sep 12;40(19):2971-90.Ras farnesyltransferase: a new therapeutic target. | ||||
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