Drug General Information
Drug ID	D0W3BA
Former ID	DIB003305
Drug Name	Methanesulfonyl fluoride
Synonyms	Fluoride; Methanesulfonyl fluoride (oral, Alzheimer's disease/cognitive disorder)
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 2	[549186]
Company	University of Texas
Structure		Download 2D MOL 3D MOL
Formula	CH3FO2S
Canonical SMILES	S(=O)(=O)(F)C
PubChem Compound ID	11207
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[532098]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 549186	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033430)
Ref 532098	A randomized phase I study of methanesulfonyl fluoride, an irreversible cholinesterase inhibitor, for the treatment of Alzheimer's disease. Br J Clin Pharmacol. 2013 May;75(5):1231-9.

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