| Drug General Information |
| Drug ID |
D0W3VT
|
| Former ID |
DNC007730
|
| Drug Name |
1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C24H24ClNO
|
| Canonical SMILES |
C1CN(CCC1(C2=CC=C(C=C2)Cl)O)C(C3=CC=CC=C3)C4=CC=CC=C4
|
| InChI |
1S/C24H24ClNO/c25-22-13-11-21(12-14-22)24(27)15-17-26(18-16-24)23(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-14,23,27H,15-18H2
|
| InChIKey |
LTTPWCPNNZPPLF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Nociceptin receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Mu-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
|
|
Estrogen signaling pathway
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Morphine addictionhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Opioid prodynorphin pathway
|
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Pathway Interaction Database
|
IL4-mediated signaling events
|
|
Reactome
|
Peptide ligand-binding receptors
|
|
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP69:TCR Signaling Pathway
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Opioid Signalling
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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|
GPCR downstream signaling
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. |
|---|
