Drug General Information
Drug ID	D0W4XY
Former ID	DCL000938
Drug Name	PRX-08066
Drug Type	Small molecular drug
Indication	Pulmonary arterial hypertension [ICD9: 416; ICD10:I27.0, I27.2]		Phase 2	[536294]
Company	Predix Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C19H17ClFN5S
PubChem Compound ID	11502243
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Antagonist	[536294]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 536294	Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
Ref 536294	Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.

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