Drug Information

Drug General Information
Drug ID
D0W7DP
Former ID
DIB013688
Drug Name
TDI-0107
Synonyms
Gene therapy (SOD1 gene inhibitor), ALS Therapy Development Foundation
Indication Motor neurone disease [ICD9: 335.2; ICD10:G12.2] Investigative [528378]
Company
ALS Therapy Development Foundation Inc
Target and Pathway
Target(s) Superoxide dismutase [Cu-Zn] Target Info Inhibitor [528378]
BioCyc Pathway Reactive oxygen species degradation
KEGG Pathway Peroxisome
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Prion diseases
NetPath Pathway TCR Signaling Pathway
Pathway Interaction Database Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor network
PathWhiz Pathway Degradation of Superoxides
Reactome Platelet degranulation
Detoxification of Reactive Oxygen Species
WikiPathways Oxidative Stress
Copper homeostasis
Detoxification of Reactive Oxygen Species
Nifedipine Activity
Amyotrophic lateral sclerosis (ALS)
Dopamine metabolism
AGE/RAGE pathway
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 528378Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
Ref 528378Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.

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