Drug General Information
Drug ID
D0W7WC
Former ID
DNAP001684
Drug Name
Ivacaftor
Synonyms
Kalydeco (TN)
Drug Type
Small molecular drug
Indication Cystic fibrosis [ICD9: 277; ICD10:E84] Approved [467679], [532210]
Company
Vertex
Structure
Download
2D MOL

3D MOL

Formula
C24H28N2O3
InChI
InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey
PURKAOJPTOLRMP-UHFFFAOYSA-N
CAS Number
CAS 873054-44-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:66901
SuperDrug ATC ID
R07AX02
Target and Pathway
Target(s) cystic fibrosis transmembrane conductance regulator Target Info Modulator [551871]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 467679(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4342).
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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