Drug Information

Drug General Information
Drug ID
D0W8SJ
Former ID
DAP000475
Drug Name
Minaprine
Synonyms
Brantur; Cantor; Minaprina; Minaprinum; Minaprine dihydrochloride; AGR 1240; CB 30038; Cantor (TN); Minaprina [INN-Spanish]; Minaprinum [INN-Latin]; Minaprine (USAN/INN); Minaprine [USAN:BAN:INN]; N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine; 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine; 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine; 4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin; 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
Drug Type
Small molecular drug
Indication Depression; Cerebral infarction [ICD9: 311; ICD10:F30-F39, I63] Approved [536164], [551871]
Therapeutic Class
Antidepressants
Structure
Download
2D MOL

3D MOL
Formula
C17H22N4O
Canonical SMILES
CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
InChI
1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)
InChIKey
LDMWSLGGVTVJPG-UHFFFAOYSA-N
CAS Number
CAS 25905-77-5
PubChem Compound ID
4199
PubChem Substance ID
7433695, 8152626, 11112706, 11335238, 11360477, 11364228, 11366790, 11369352, 11372508, 11373855, 11377514, 11461449, 11466094, 11467214, 11485190, 11485908, 11489223, 11491260, 11492233, 11495148, 14751646, 24896803, 29223304, 46505380, 47206766, 47216618, 47290970, 47440078, 47588828, 47662107, 47959567, 47959568, 49698916, 49993893, 50100510, 56394929, 57322189, 57654369, 61212480, 77581144, 85209879, 85787830, 103140727, 103194634, 103967506, 104024299, 104305716, 117523812, 124599829, 124882544
ChEBI ID
ChEBI:51038
SuperDrug ATC ID
N06AX07
SuperDrug CAS ID
cas=025905775
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Antagonist [535814], [536549]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536164Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease. Expert Opin Investig Drugs. 2006 Jan;15(1):1-12.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535814Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia. Jpn J Pharmacol. 1992 Sep;60(1):33-8.
Ref 536549Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.

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