Drug Information

Drug General Information
Drug ID
D0W8UW
Former ID
DNC013314
Drug Name
AMG-628
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [467475]
Structure
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2D MOL

3D MOL
Formula
C25H25FN6O2S
InChI
InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)/t16-/m1/s1
InChIKey
QUHZTEMPQQZPNB-MRXNPFEDSA-N
PubChem Compound ID
11352366
PubChem Substance ID
16444051, 23511091, 42431654, 49688655, 78260489, 103521376, 123071346, 134350519, 137420231, 142821536, 172650464, 178100952, 187612797, 189481960, 198942939, 198963661, 215792993, 223960040, 229822825, 245034036
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Inhibitor [528915]
Vanilloid receptor Target Info Inhibitor [528915]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 467475(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4130).
Ref 528915J Med Chem. 2007 Jul 26;50(15):3528-39. Epub 2007 Jun 22.Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.

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