Drug Information

Drug General Information
Drug ID
D0W8WZ
Former ID
DIB020691
Drug Name
Pfizer compound 67
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529445], [541125]
Structure
Download
2D MOL
Formula
C31H34N4O2
InChI
InChI=1S/C31H34N4O2/c1-3-23-11-7-9-15-28(23)35-30(21-22(2)34-35)37-29-16-10-8-14-27(29)33-31(36)32-26-19-17-25(18-20-26)24-12-5-4-6-13-24/h7-11,14-21,24H,3-6,12-13H2,1-2H3,(H2,32,33,36)
InChIKey
BLOWXIFVYOKSMX-UHFFFAOYSA-N
PubChem Compound ID
24743975
PubChem Substance ID
49637528, 56161462, 103563858, 141846922, 160852405, 178102430, 230793765, 245898962
Target and Pathway
Target(s) P2Y purinoceptor 1 Target Info Antagonist [529445]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 529445Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. Epub 2008 Apr 15.P2Y1 receptor antagonists as novel antithrombotic agents.
Ref 541125(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5805).
Ref 529445Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. Epub 2008 Apr 15.P2Y1 receptor antagonists as novel antithrombotic agents.

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