Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W9LJ
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| Former ID |
DNC003294
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| Drug Name |
Metiamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C9H16N4S2
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| InChI |
InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
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| InChIKey |
FPBPLBWLMYGIQR-UHFFFAOYSA-N
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| CAS Number |
CAS 34839-70-8
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9652, 454502, 6698911, 8653311, 14774170, 16961280, 17398245, 32248923, 47434826, 47954439, 50061391, 50222525, 57409062, 71922618, 85229947, 89651662, 95515649, 99445275, 103173533, 103914964, 109612907, 110525148, 127879114, 131342042, 134221816, 134998461, 135650597, 137156409, 137263792, 152343567, 160969712, 162011533, 163415887, 163620956, 163686278, 163910534, 166729885, 172868618, 174529016, 179293854, 185990418, 198939253, 223440325, 223563202, 224774955, 226845005, 236556847, 242060280, 249962168, 252215738
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| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1233). | ||||
| REF 2 | Metiamide—an orally active histamine H2-receptor antagonist. 1973. Agents Actions. 1994 Dec;43(3-4):91-5; discussion 96. | ||||
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