Drug General Information
Drug ID	D0W9NO
Former ID	DIB013788
Drug Name	YT-146
Synonyms	Adenosine A2 agonists, Yamasa
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Phase 2	[544864]
Company	Yamasa Shoyu Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C18H25N5O4
Canonical SMILES	n1(c2c(nc1)c(nc(n2)C#CCCCCCC)N)[C@H]1[C@@H]([C@@H]([C@H<br />](O1)CO)O)O
CAS Number	CAS 90596-75-1
PubChem Compound ID	146207
Target and Pathway
Target(s)	Adenosine A2b receptor	Target Info	Agonist	[533910]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Alcoholism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544864	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001363)
Ref 533910	Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10.

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