Drug General Information
Drug ID
D0W9OR
Former ID
DAP001334
Drug Name
OspA lipoprotein
Drug Type
Vaccine
Indication Lyme disease [ICD9: 88.81; ICD10:A69.2] Approved [536381]
Therapeutic Class
Vaccines
Formula
C1198H2012N322O422S2
Target and Pathway
Target(s) B-cell receptor CD22 Target Info Binder [534840]
KEGG Pathway Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
B cell receptor signaling pathway
PANTHER Pathway B cell activation
Pathway Interaction Database BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways B Cell Receptor Signaling Pathway
References
Ref 536381Infection of mice with lyme disease spirochetes constitutively producing outer surface proteins a and B. Infect Immun. 2007 Jun;75(6):2786-94. Epub 2007 Mar 19.
Ref 534840Safety and immunogenicity of recombinant Bacille Calmette-Gu?|rin (rBCG) expressing Borrelia burgdorferi outer surface protein A (OspA) lipoprotein in adult volunteers: a candidate Lyme disease vaccine. Vaccine. 1999 Feb 26;17(7-8):904-14.

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