Drug General Information
Drug ID	D0W9VA
Former ID	DNC003523
Drug Name	1,2-NAPHTHOQUINONE
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529103]
Structure		Download 2D MOL 3D MOL
Formula	C10H6O2
Canonical SMILES	C1=CC=C2C(=C1)C=CC(=O)C2=O
InChI	1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H
InChIKey	KETQAJRQOHHATG-UHFFFAOYSA-N
PubChem Compound ID	10667
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[529103]
	Indoleamine 2,3-dioxygenase	Target Info	Inhibitor	[529353]
	Liver carboxylesterase	Target Info	Inhibitor	[529103]
	mRNA of Protein tyrosine phosphatase-1B	Target Info	Inhibitor	[526377]
	Cholinesterase	Target Info	Inhibitor	[529103]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation
	L-kynurenine degradation
	Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
	NAD de novo biosynthesis
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapsehsa00380:Tryptophan metabolism
	Metabolic pathways
	African trypanosomiasishsa00983:Drug metabolism - other enzymes
	Metabolic pathwayshsa04520:Adherens junction
	Insulin signaling pathway
NetPath Pathway	TSLP Signaling Pathway
	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathwayP00012:Cadherin signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor networke2f_pathway:E2F transcription factor networkinsulin_pathway:Insulin Pathway
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Signaling events mediated by PTP1B
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Signaling events mediated by TCPTP
	IGF1 pathway
	EGF receptor (ErbB1) signaling pathway
	Posttranslational regulation of adherens junction stability and dissassembly
	PDGFR-beta signaling pathway
	N-cadherin signaling events
PathWhiz Pathway	Phospholipid BiosynthesisPW000163:Tryptophan Metabolism
Reactome	Tryptophan catabolismR-HSA-354192:Integrin alphaIIb beta3 signaling
	Regulation of IFNG signaling
	Regulation of IFNA signaling
	Growth hormone receptor signaling
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer PathwayWP465:Tryptophan metabolism
	Metabolism of amino acids and derivativesWP2884:NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450WP481:Insulin Signaling
	Growth hormone receptor signaling
	Leptin signaling pathway
	Interferon gamma signaling
	Interferon alpha/beta signaling
	Integrin alphaIIb beta3 signalingWP229:Irinotecan Pathway
References
Ref 529103	J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 526377	Bioorg Med Chem Lett. 2002 Aug 5;12(15):1941-6.Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Ref 529103	J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 529353	J Med Chem. 2008 Mar 27;51(6):1706-18. Epub 2008 Mar 5.Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

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