| Drug General Information |
| Drug ID |
D0WN7V
|
| Former ID |
DNC011361
|
| Drug Name |
NSC-180246
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H14O5
|
| Canonical SMILES |
CC1=C(C=C2C(=C1O)C(=O)CC(O2)C3=CC=C(C=C3)O)O
|
| InChI |
1S/C16H14O5/c1-8-11(18)6-14-15(16(8)20)12(19)7-13(21-14)9-2-4-10(17)5-3-9/h2-6,13,17-18,20H,7H2,1H3
|
| InChIKey |
SLFZBNOERHGNMI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Voltage-dependent N-type calcium channel |
Target Info |
Inhibitor |
[1]
|
|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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MAPK signaling pathway
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Calcium signaling pathway
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Synaptic vesicle cycle
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Retrograde endocannabinoid signaling
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Taste transduction
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Type II diabetes mellitus
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Morphine addiction
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Nicotine addictionhsa04151:PI3K-Akt signaling pathway
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MicroRNAs in cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group II pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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Endogenous cannabinoid signaling
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GABA-B receptor II signalingP00006:Apoptosis signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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E2F transcription factor network
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Direct p53 effectors
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IL6-mediated signaling events
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HIF-1-alpha transcription factor network
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Reactome
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Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
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WikiPathways
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Calcium Regulation in the Cardiac Cell
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Synaptic Vesicle PathwayWP254:Apoptosis
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in leukocytes - TarBase
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Apoptosis Modulation and Signaling
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). |
|---|
