Drug General Information |
Drug ID |
D0WY2N
|
Former ID |
DNC003975
|
Drug Name |
VK-19911
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C19H19FN4
|
Canonical SMILES |
C1CNCCC1N2C=NC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F
|
InChI |
1S/C19H19FN4/c20-16-3-1-14(2-4-16)18-19(15-5-9-21-10-6-15)24(13-23-18)17-7-11-22-12-8-17/h1-6,9-10,13,17,22H,7-8,11-12H2
|
InChIKey |
QBACMJFLMUCPNA-UHFFFAOYSA-N
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PubChem Compound ID |
|
Target and Pathway |
Target(s) |
MAP kinase p38 |
Target Info |
Inhibitor |
[1]
|
Mitogen-activated protein kinase 11 |
Target Info |
Inhibitor |
[1]
|
Mitogen-activated protein kinase 14 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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MAPK signaling pathway
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Rap1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Oocyte meiosis
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Amyotrophic lateral sclerosis (ALS)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Influenza A
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Epstein-Barr virus infection
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Proteoglycans in cancerhsa04010:MAPK signaling pathway
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Proteoglycans in cancer
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NetPath Pathway
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TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
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FSH Signaling Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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B cell activation
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EGF receptor signaling pathway
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FGF signaling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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Parkinson disease
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TGF-beta signaling pathway
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Ras Pathway
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p53 pathway feedback loops 2
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p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Toll receptor signaling pathway
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VEGF signaling pathway
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p38 MAPK pathway
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CCKR signaling map ST
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Pathway Interaction Database
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RhoA signaling pathway
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Signaling mediated by p38-gamma and p38-deltap73pathway:p73 transcription factor network
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p38 MAPK signaling pathway
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Plasma membrane estrogen receptor signaling
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CD40/CD40L signaling
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Regulation of p38-alpha and p38-beta
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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ATF-2 transcription factor network
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IL6-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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Signaling events mediated by VEGFR1 and VEGFR2
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VEGFR3 signaling in lymphatic endothelium
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Regulation of retinoblastoma proteinendothelinpathway:Endothelins
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BCR signaling pathway
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p73 transcription factor network
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Atypical NF-kappaB pathway
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IL4-mediated signaling events
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IL12-mediated signaling events
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CDC42 signaling events
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Angiopoietin receptor Tie2-mediated signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Regulation of Androgen receptor activity
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Retinoic acid receptors-mediated signaling
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EPO signaling pathway
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p53 pathway
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S1P2 pathway
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Trk receptor signaling mediated by the MAPK pathway
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FGF signaling pathway
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RAC1 signaling pathway
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Regulation of retinoblastoma protein
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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NOD1/2 Signaling Pathway
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p38MAPK events
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
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CDO in myogenesis
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DSCAM interactions
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VEGFA-VEGFR2 PathwayR-HSA-168638:NOD1/2 Signaling Pathway
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ERK/MAPK targets
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Oxidative Stress Induced Senescence
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VEGFA-VEGFR2 Pathway
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activated TAK1 mediates p38 MAPK activation
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Activation of the AP-1 family of transcription factors
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KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
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ADP signalling through P2Y purinoceptor 1
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Platelet sensitization by LDL
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KSRP (KHSRP) binds and destabilizes mRNA
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WikiPathways
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Toll-like receptor signaling pathway
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Insulin Signaling
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MAPK Cascade
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MAPK Signaling Pathway
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Nanoparticle-mediated activation of receptor signaling
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Signal Transduction of S1P Receptor
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Parkinsons Disease Pathway
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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NGF signalling via TRKA from the plasma membrane
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Myogenesis
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Integrin-mediated Cell Adhesion
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DSCAM interactions
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Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
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IL-4 Signaling Pathway
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MAP kinase activation in TLR cascade
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
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Structural Pathway of Interleukin 1 (IL-1)
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Physiological and Pathological Hypertrophy of the Heart
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Monoamine Transport
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Serotonin HTR1 Group and FOS Pathway
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TCR Signaling Pathway
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Senescence and Autophagy in Cancer
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Interferon type I signaling pathways
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EGF/EGFR Signaling Pathway
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Oxidative Stress
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p38 MAPK Signaling Pathway
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TGF beta Signaling Pathway
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Kit receptor signaling pathway
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Cardiac Hypertrophic Response
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JAK/STAT
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Amyotrophic lateral sclerosis (ALS)
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Alpha 6 Beta 4 signaling pathway
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Cardiac Progenitor Differentiation
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BDNF signaling pathway
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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B Cell Receptor Signaling Pathway
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Prostate Cancer
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
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FSH signaling pathway
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Leptin signaling pathway
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RANKL/RANK Signaling Pathway
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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IL-1 signaling pathway
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Signal amplification
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Platelet homeostasis
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MicroRNAs in cardiomyocyte hypertrophy
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Angiogenesis
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Regulation of toll-like receptor signaling pathway
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References |
REF 1 | J Med Chem. 2003 Dec 18;46(26):5651-62.Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. |