Drug Information

Drug General Information
Drug ID
D0WY5Q
Former ID
DIB002950
Drug Name
Rivastigmine
Synonyms
Rivastigmine (transdermal patch)
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Approved [522744], [541722]
Company
Samyang Corp
Structure
Download
2D MOL

3D MOL
Formula
C14H22N2O2
InChI
InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
InChIKey
XSVMFMHYUFZWBK-NSHDSACASA-N
PubChem Compound ID
77991
PubChem Substance ID
13930, 7980526, 8199304, 14774320, 15122215, 17397908, 43133576, 46507452, 46511221, 46512204, 48416523, 50064280, 50112784, 50261541, 57332462, 92308834, 93166474, 99246076, 103188932, 104368723, 117695400, 126617420, 126651532, 126664492, 129736061, 131345536, 134337471, 135035468, 135668168, 136947990, 137003256, 137550927, 152035753, 160647611, 160964326, 162210022, 163621046, 164825741, 174006853, 174531833, 175268589, 175605731, 175612189, 176484202, 178103215, 179116882, 184546191, 185974791, 196106102, 223368211
Target and Pathway
Target(s) Acetylcholinesterase Target Info Modulator [543634]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 522744ClinicalTrials.gov (NCT00948766) Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44. U.S. National Institutes of Health.
Ref 541722(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6602).
Ref 543634(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).

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