Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X2MZ
|
||||
| Former ID |
DIB008805
|
||||
| Drug Name |
Syn-1020
|
||||
| Synonyms |
NOP agonist peptide (pain), SynVax; ORL1 agonist peptide (pain), SynVax; Ac-RY(3-Cl)YRWR-NH2
|
||||
| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Investigative | [1] | ||
| Company |
Synvax Pharmaceuticals Inc
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N<br />[C@H](C(=O)N[C@H](C(=O)N)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)C<br />CCNC(=N)N)Cc1cc(c(cc1)O)Cl)Cc1ccc(cc1)O)CCCNC(=N)N
|
||||
| Target and Pathway | |||||
| Target(s) | Nociceptin receptor | Target Info | Agonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.