Drug Information

Drug General Information
Drug ID
D0X5NX
Former ID
DAP000945
Drug Name
Clenbuterol
Synonyms
Clenbuterolum; Contraspasmin; Planipart; Planipart [veterinary]; Clenbuterol (INN); Clenbuterol [BAN:INN]; Clenbuterolum [INN-Latin]; Contraspasmin (TN); NAB-365; Planipart [veterinary] (TN); (+)-4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol; (+-)-clenbuterol; (-)-4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol; 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanol; 1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol; 1-(4-amino-3,5-dichlorophenyl)-2-[(1,1-dimethylethyl)amino]ethanol; 4-Amino-3,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol; 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol
Drug Type
Small molecular drug
Indication Chronic breathing disorders [ICD9: 490-496; ICD10:J44-J47] Approved [550744]
Therapeutic Class
Bronchodilator Agents
Structure
Download
2D MOL

3D MOL
Formula
C12H18Cl2N2O
Canonical SMILES
CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O
InChI
1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3
InChIKey
STJMRWALKKWQGH-UHFFFAOYSA-N
CAS Number
CAS 37148-27-9
PubChem Compound ID
2783
PubChem Substance ID
4445365, 7980738, 8151795, 11335969, 11361208, 11364458, 11367020, 11369582, 11371928, 11374205, 11374656, 11377744, 11462180, 11466373, 11467493, 11486066, 11490790, 11492558, 11492913, 11495378, 15222099, 26756514, 29216418, 29221938, 46508373, 47216807, 47589036, 47885449, 47959784, 48035160, 48110483, 48334530, 48415793, 49698946, 49880554, 50111385, 50111386, 50294329, 51092009, 53789319, 56312093, 56312823, 56312919, 57321457, 57560470, 85084908, 85373776, 85788859, 85856301, 92308851
SuperDrug ATC ID
R03AC14; R03CC13
SuperDrug CAS ID
cas=037148279
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [535304], [536989]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 550744Drug information of Clenbuterol, 2008. eduDrugs.
Ref 535304Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Neuroscience. 2001;107(4):593-602.
Ref 536989Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg. 2009 Jan;108(1):280-7.

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