| Drug General Information |
| Drug ID |
D0X6MT
|
| Former ID |
DNC003558
|
| Drug Name |
METHIOTHEPIN
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H24N2S2
|
| InChI |
InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
|
| InChIKey |
RLJFTICUTYVZDG-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7816804, 7979277, 8152575, 11336088, 11361327, 11372522, 11374642, 11406693, 11462299, 11466403, 11467523, 11485829, 11486186, 11489783, 11491417, 11492906, 12012717, 14828076, 24263002, 26751783, 29223214, 47216839, 47662350, 47736555, 47810816, 47810817, 47885476, 47885477, 48035204, 48110512, 48334574, 49698953, 50012693, 50104468, 50104469, 50104470, 50256032, 53790360, 57322144, 85209172, 85787800, 85788848, 90341652, 92308987, 103046125, 103307762, 104015431, 104305443, 109612645, 124750013
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 7 receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Inhibitor |
[3]
|
| 5-hydroxytryptamine 5A receptor |
Target Info |
Inhibitor |
[4]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
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cAMP signaling pathway
|
|
Serotonergic synapse
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
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GPCR downstream signaling
|
|
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 89). |
|---|
| REF 2 | Bioorg Med Chem. 2008 Mar 1;16(5):2570-8. Epub 2007 Nov 22.Novel quinazolinone derivatives as 5-HT7 receptor ligands. |
|---|
| REF 3 | J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. |
|---|
| REF 4 | J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). |
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