Drug Information

Drug General Information
Drug ID
D0X6MT
Former ID
DNC003558
Drug Name
METHIOTHEPIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543281]
Structure
Download
2D MOL

3D MOL
Formula
C20H24N2S2
InChI
InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
InChIKey
RLJFTICUTYVZDG-UHFFFAOYSA-N
PubChem Compound ID
4106
PubChem Substance ID
7816804, 7979277, 8152575, 11336088, 11361327, 11372522, 11374642, 11406693, 11462299, 11466403, 11467523, 11485829, 11486186, 11489783, 11491417, 11492906, 12012717, 14828076, 24263002, 26751783, 29223214, 47216839, 47662350, 47736555, 47810816, 47810817, 47885476, 47885477, 48035204, 48110512, 48334574, 49698953, 50012693, 50104468, 50104469, 50104470, 50256032, 53790360, 57322144, 85209172, 85787800, 85788848, 90341652, 92308987, 103046125, 103307762, 104015431, 104305443, 109612645, 124750013
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Inhibitor [529222]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [530739]
5-hydroxytryptamine 5A receptor Target Info Inhibitor [526655]
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP58:Monoamine GPCRs
References
Ref 543281(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 89).
Ref 526655J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Ref 529222Bioorg Med Chem. 2008 Mar 1;16(5):2570-8. Epub 2007 Nov 22.Novel quinazolinone derivatives as 5-HT7 receptor ligands.
Ref 530739J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.

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