TTD | Drug: D0X6QL

Drug General Information
Drug ID	D0X6QL
Former ID	DIB018014
Drug Name	KGP94
Drug Type	Small molecular drug
Indication	Coagulation [ICD10:I80-I82]		Clinical trial	[541661]
Structure		Download 2D MOL 3D MOL
Formula	C14H12BrN3OS
InChI	InChI=1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)/b17-13-
InChIKey	ZDBKSZKTCPOBFR-LGMDPLHJSA-N
PubChem Compound ID	52944285
PubChem Substance ID	123090349, 123109145, 176482707
Target and Pathway
Target(s)	Cathepsin L	Target Info	Inhibitor	[531200]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Proteoglycans in cancer
	Rheumatoid arthritis
NetPath Pathway	IL4 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Collagen degradation
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 541661	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6533).
Ref 531200	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

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Drug Information