| Drug General Information |
| Drug ID |
D0X7IC
|
| Former ID |
DIB020530
|
| Drug Name |
NG-25
|
| Synonyms |
NG25
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C29H30F3N5O2
|
| InChI |
InChI=1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)
|
| InChIKey |
SMPGEBOIKULBCT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[1]
|
|---|
| c-src tyrosine kinase |
Target Info |
Inhibitor |
[1]
|
| Lyn tyrosine kinase |
Target Info |
Inhibitor |
[1]
|
| Mitogen-activated protein kinase kinase kinase 7 |
Target Info |
Inhibitor |
[1]
|
| mitogen-activated protein kinase kinase kinase kinase 2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
ErbB signaling pathway
|
|
Rap1 signaling pathway
|
|
Chemokine signaling pathway
|
|
Endocytosis
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Adherens junction
|
|
Tight junction
|
|
Gap junction
|
|
Platelet activation
|
|
GABAergic synapse
|
|
Inflammatory mediator regulation of TRP channels
|
|
Regulation of actin cytoskeleton
|
|
GnRH signaling pathway
|
|
Estrogen signaling pathway
|
|
Prolactin signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Bacterial invasion of epithelial cells
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Shigellosis
|
|
Tuberculosis
|
|
Hepatitis B
|
|
Viral carcinogenesis
|
|
Proteoglycans in cancerhsa04062:Chemokine signaling pathway
|
|
NF-kappa B signaling pathway
|
|
B cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
Long-term depression
|
|
Epstein-Barr virus infection
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
|
FSH Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
Cadherin signaling pathway
|
|
Integrin signalling pathway
|
|
Parkinson disease
|
|
CCKR signaling map STP00010:B cell activation
|
|
CCKR signaling map STP00052:TGF-beta signaling pathway
|
|
Toll receptor signaling pathway
|
|
Wnt signaling pathway
|
|
p38 MAPK pathway
|
|
Pathway Interaction Database
|
Endothelins
|
|
Signaling events mediated by PRL
|
|
LPA receptor mediated events
|
|
Atypical NF-kappaB pathway
|
|
Glypican 1 network
|
|
Plasma membrane estrogen receptor signaling
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Signaling events mediated by PTP1B
|
|
S1P3 pathway
|
|
EPHB forward signaling
|
|
Nectin adhesion pathway
|
|
Regulation of p38-alpha and p38-beta
|
|
CDC42 signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Arf6 signaling events
|
|
Signaling events mediated by TCPTP
|
|
FAS (CD95) signaling pathway
|
|
Thromboxane A2 receptor signaling
|
|
Netrin-mediated signaling events
|
|
Alpha9 beta1 integrin signaling events
|
|
CXCR4-mediated signaling events
|
|
EGF receptor (ErbB1) signaling pathway
|
|
Class I PI3K signaling events
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
Regulation of Androgen receptor activity
|
|
E-cadherin signaling in the nascent adherens junction
|
|
amb2 Integrin signaling
|
|
Integrins in angiogenesis
|
|
ErbB1 downstream signaling
|
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
|
ErbB2/ErbB3 signaling events
|
|
EPHA forward signaling
|
|
E-cadherin signaling in keratinocytes
|
|
PDGFR-beta signaling pathway
|
|
Nongenotropic Androgen signaling
|
|
Internalization of ErbB1
|
|
CXCR3-mediated signaling events
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Syndecan-2-mediated signaling events
|
|
Class I PI3K signaling events mediated by Akt
|
|
Syndecan-3-mediated signaling events
|
|
Ephrin B reverse signaling
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
EPHA2 forward signaling
|
|
Alpha-synuclein signaling
|
|
FGF signaling pathway
|
|
Alpha4 beta1 integrin signaling events
|
|
Signaling events mediated by focal adhesion kinasefcer1pathway:Fc-epsilon receptor I signaling in mast cells
|
|
BCR signaling pathway
|
|
GMCSF-mediated signaling events
|
|
IL5-mediated signaling events
|
|
IL8- and CXCR2-mediated signaling events
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
EPO signaling pathway
|
|
IL8- and CXCR1-mediated signaling events
|
|
Alpha-synuclein signalingbcr_5pathway:BCR signaling pathway
|
|
p38 MAPK signaling pathway
|
|
Noncanonical Wnt signaling pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
IL1-mediated signaling events
|
|
TNF receptor signaling pathway
|
|
BMP receptor signaling
|
|
JNK signaling in the CD4+ TCR pathway
|
|
C-MYB transcription factor network
|
|
TGF-beta receptor signaling
|
|
PathWhiz Pathway
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Reactome
|
GPVI-mediated activation cascade
|
|
Regulation of KIT signaling
|
|
Cell surface interactions at the vascular wall
|
|
FCGR activation
|
|
PECAM1 interactions
|
|
Fc epsilon receptor (FCERI) signaling
|
|
EPH-Ephrin signaling
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
|
FCERI mediated MAPK activation
|
|
FCERI mediated Ca+2 mobilization
|
|
FCERI mediated NF-kB activation
|
|
CD28 co-stimulation
|
|
CTLA4 inhibitory signaling
|
|
EPHB-mediated forward signaling
|
|
EPHA-mediated growth cone collapse
|
|
EPH-ephrin mediated repulsion of cells
|
|
Dectin-2 family
|
|
CD209 (DC-SIGN) signaling
|
|
Platelet Adhesion to exposed collagen
|
|
Regulation of signaling by CBL
|
|
Growth hormone receptor signaling
|
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-1169091:Activation of NF-kappaB in B cells
|
|
NOD1/2 Signaling Pathway
|
|
Ca2+ pathway
|
|
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
|
Interleukin-1 signaling
|
|
activated TAK1 mediates p38 MAPK activation
|
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
|
TNFR1-induced NFkappaB signaling pathway
|
|
CLEC7A (Dectin-1) signaling
|
|
TRAF6 mediated induction of TAK1 complex
|
|
WikiPathways
|
ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
|
Pregnane X Receptor pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
IL-3 Signaling Pathway
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Polycystic Kidney Disease Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
Signaling Pathways in Glioblastoma
|
|
TSLP Signaling Pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrin-mediated Cell Adhesion
|
|
Angiogenesis
|
|
Androgen receptor signaling pathwayWP304:Kit receptor signaling pathway
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Signaling by the B Cell Receptor (BCR)
|
|
Signaling by SCF-KIT
|
|
Growth hormone receptor signaling
|
|
B Cell Receptor Signaling Pathway
|
|
Platelet Adhesion to exposed collagen
|
|
GPVI-mediated activation cascade
|
|
Costimulation by the CD28 family
|
|
Cell surface interactions at the vascular wall
|
|
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
|
|
DNA Damage Response (only ATM dependent)
|
|
TCR Signaling Pathway
|
|
Insulin Signaling
|
|
p38 MAPK Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
MAPK Signaling Pathway
|
|
IL-6 signaling pathway
|
|
FAS pathway and Stress induction of HSP regulation
|
|
NLR Proteins
|
|
MyD88 cascade initiated on plasma membrane
|
|
Cardiac Hypertrophic Response
|
|
MAP kinase activation in TLR cascade
|
|
MyD88 dependent cascade initiated on endosome
|
|
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
|
|
MyD88:Mal cascade initiated on plasma membrane
|
|
MyD88-independent cascade
|
|
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
EBV LMP1 signaling
|
|
TNF alpha Signaling Pathway
|
|
IL17 signaling pathway
|
|
TWEAK Signaling Pathway
|
|
IL-1 signaling pathway
|
|
TCR signaling
|
|
Interleukin-1 signaling
|
|
Regulation of toll-like receptor signaling pathway
|
| References |
| REF 1 | Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. |
|---|
