Drug Information

Drug General Information
Drug ID
D0X7VM
Former ID
DNC007829
Drug Name
KYS-05090
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529566]
Structure
Download
2D MOL

3D MOL
Formula
C37H43N5O
Canonical SMILES
CN(C)CCCCCN(C)C1=NC2=CC=CC=C2C(N1C3=CC=C(C=C3)C4=CC=CC=<br />C4)CC(=O)NCC5=CC=CC=C5
InChI
1S/C37H43N5O/c1-40(2)25-13-6-14-26-41(3)37-39-34-20-12-11-19-33(34)35(27-36(43)38-28-29-15-7-4-8-16-29)42(37)32-23-21-31(22-24-32)30-17-9-5-10-18-30/h4-5,7-12,15-24,35H,6,13-14,25-28H2,1-3H3,(H,38,43)
InChIKey
QVXCZTNUVKNCGU-UHFFFAOYSA-N
PubChem Compound ID
23661603
Target and Pathway
Target(s) Voltage-dependent N-type calcium channel Target Info Inhibitor [529044]
Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Inhibitor [529566]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addictionhsa04010:MAPK signaling pathway
Circadian entrainment
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signalingP05730:Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart Contraction
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium ChannelsR-HSA-419037:NCAM1 interactions
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle PathwayWP1866:NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin Cells
References
Ref 529566Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Ref 529044Bioorg Med Chem Lett. 2007 Nov 1;17(21):5740-3. Epub 2007 Sep 1.Discovery of potent T-type calcium channel blocker.
Ref 529566Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.

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