Drug Information

Drug General Information
Drug ID
D0X8XT
Former ID
DNCL003441
Drug Name
CS-0777
Drug Type
Small molecular drug
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Phase 1 [522226]
Company
Daiichi Sankyo
Structure
Download
2D MOL

3D MOL
Formula
C21H30N2O2
Canonical SMILES
CC1=CC=C(C=C1)CCCC(=O)C2=CC=C(N2C)CCC(C)(CO)N
InChI
1S/C21H30N2O2/c1-16-7-9-17(10-8-16)5-4-6-20(25)19-12-11-18(23(19)3)13-14-21(2,22)15-24/h7-12,24H,4-6,13-15,22H2,1-3H3/t21-/m1/s1
InChIKey
YXEQXPNSBUIRDZ-OAQYLSRUSA-N
PubChem Compound ID
11371290
PubChem Substance ID
16464453, 23526482, 42450519, 79565976, 135267610, 136930027, 139834657, 224117361, 227663318, 248819105, 249492302, 249820179
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Modulator [531862], [532807]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 522226ClinicalTrials.gov (NCT00616733) 12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients. U.S. National Institutes of Health.
Ref 531862Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. J Neuroimmunol. 2012 May 15;246(1-2):100-7.
Ref 532807Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72.

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