Drug General Information
Drug ID	D0XE5L
Former ID	DIB005132
Drug Name	Rispenzepine
Synonyms	Nuvenzepine; DF-545
Drug Type	Small molecular drug
Indication	Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47]		Discontinued in Phase 2	[545564]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Formula	C19H20N4O2
Canonical SMILES	n1(c2c(c(=O)[nH]c3c1cccc3)cccn2)C(=O)C1CN(CCC1)C
PubChem Compound ID	129505
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M1	Target Info	Antagonist	[537849]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545564	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003718)
Ref 537849	Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med. 1995 Sep;152(3):872-8.

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