Drug Information

Drug General Information
Drug ID
D0XR8Q
Former ID
DIB019980
Drug Name
GW2433
Synonyms
GW 2433; GW-2433
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539776]
Structure
Download
2D MOL
Formula
C28H28Cl3FN2O4
InChI
InChI=1S/C28H28Cl3FN2O4/c1-28(2,26(35)36)38-19-13-11-18(12-14-19)6-5-16-34(17-15-20-21(29)7-3-9-23(20)32)27(37)33-24-10-4-8-22(30)25(24)31/h3-4,7-14H,5-6,15-17H2,1-2H3,(H,33,37)(H,35,36)
InChIKey
YMWJDWJXIXITMD-UHFFFAOYSA-N
PubChem Compound ID
1517
PubChem Substance ID
821157, 5568775, 7885313, 8151163, 14764529, 17396614, 24439845, 52712993, 57320926, 58097850, 103399341, 104297945, 135650332, 137183961, 143260277, 228183024, 245714969
Target and Pathway
Target(s) Peroxisomeproliferator activated receptor delta Target Info Agonist [534536]
KEGG Pathway PPAR signaling pathway
Wnt signaling pathway
Pathways in cancer
Acute myeloid leukemia
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptor
Reactome Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway and Pluripotency
Nuclear Receptors in Lipid Metabolism and Toxicity
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Adipogenesis
Nuclear Receptors
References
Ref 539776(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2716).
Ref 534536Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Chem Biol. 1997 Dec;4(12):909-18.

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