Drug Information

Drug General Information
Drug ID
D0XX9Y
Former ID
DIB019727
Drug Name
DH97
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540320]
Structure
Download
2D MOL
Formula
C22H26N2O
InChI
InChI=1S/C22H26N2O/c1-2-3-13-22(25)23-15-14-19-18-11-7-8-12-20(18)24-21(19)16-17-9-5-4-6-10-17/h4-12,24H,2-3,13-16H2,1H3,(H,23,25)
InChIKey
HDOIPCLEKCEANF-UHFFFAOYSA-N
PubChem Compound ID
3467177
PubChem Substance ID
4650111, 7979058, 9717593, 11113967, 15495505, 26752112, 36431905, 57356312, 78399586, 85787599, 91746291, 112260522, 126209622, 126722906, 128045479, 135697599, 136351484, 162022821, 163122532, 178100390, 204376606, 227817934, 241071796, 241182240, 241375305, 242140976, 252160071
Target and Pathway
Target(s) Melatonin receptor Target Info Antagonist [534767]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540320(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3366).
Ref 534767Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8.

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