Drug General Information
Drug ID
D0Y0SY
Former ID
DIB005001
Drug Name
E-3620
Indication Gastric motility disorder [ICD10:K22.4] Discontinued in Phase 2 [545633]
Company
Eisai Co Ltd
Structure
Download
2D MOL

3D MOL

Canonical SMILES
c1(C(=O)N[C@@H]2CC3N(C(C2)CC3)C)c(cc(c(c1)Cl)N)O[C@H](C<br />#CC)C.Cl
CAS Number
CAS 151213-85-3
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Modulator [1572591]
5-HT 3 receptor Target Info Modulator [1572591]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545633Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004004)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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