TTD | Drug: D0Y1UL

Drug General Information
Drug ID	D0Y1UL
Former ID	DNC010328
Drug Name	(E)-3-(4-hydroxybenzylidene)indolin-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530673]
Structure		Download 2D MOL 3D MOL
Formula	C15H11NO2
Canonical SMILES	C1=CC=C2C(=C1)C(=CC3=CC=C(C=C3)O)C(=O)N2
InChI	1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9+
InChIKey	PLAOAGFXNCEZMZ-UKTHLTGXSA-N
PubChem Compound ID	10561847
Target and Pathway
Target(s)	Proto-oncogene tyrosine-protein kinase receptor ret	Target Info	Inhibitor	[530673]
KEGG Pathway	Endocytosis
	Pathways in cancer
	Thyroid cancer
	Central carbon metabolism in cancer
Pathway Interaction Database	Signaling events regulated by Ret tyrosine kinase
Pathway Interaction Database	Posttranslational regulation of adherens junction stability and dissassembly
WikiPathways	SIDS Susceptibility Pathways
WikiPathways	Dopaminergic Neurogenesis
References
Ref 530673	Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
Ref 530673	Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

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Drug Information