Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Y5MF
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| Former ID |
DIB011704
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| Drug Name |
BND-001
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| Synonyms |
BND-001; NiK-001; NiK-10001; NiK-10034; NiK-18862; Nik-21273; ORL-1 antagonists (CNS disorders); ORL-1 antagonists (CNS disorders), Brane; Opioid receptor like-1 antagonists (CNS disorders), NiKem Research
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| Indication | Central nervous system disease [ICD10:G00-G99] | Investigative | [1] | ||
| Company |
NiKem Research Srl
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C(=O)(Cn1c(c(c2ccccc12)CN1CCC(CC1)c1c(cccc1F)Cl)C(=O)N1<br />CCOCC1)N
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| Target and Pathway | |||||
| Target(s) | Nociceptin receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). | ||||
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