TTD | Drug: D0Y5QR

Drug General Information
Drug ID	D0Y5QR
Former ID	DNC000112
Drug Name	8R-Lisuride
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535914]
Structure		Download 2D MOL 3D MOL
Formula	C20H26N4O
Canonical SMILES	CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
InChI	1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18-/m1/s1
InChIKey	BKRGVLQUQGGVSM-RDTXWAMCSA-N
CAS Number	CAS 18016-80-3
PubChem Compound ID	11957615
PubChem Substance ID	17405342, 23919056, 26756522, 36454879, 47646559, 47720611, 47795044, 49846681, 53777887, 57377655, 76836309, 85788551, 92304081, 124749994, 134339633, 175267560, 242326804
ChEBI ID	ChEBI:51164
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Agonist	[535914]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 535914	8R-lisuride is a potent stereospecific histamine H1-receptor partial agonist. Mol Pharmacol. 2004 Mar;65(3):538-49.
Ref 535914	8R-lisuride is a potent stereospecific histamine H1-receptor partial agonist. Mol Pharmacol. 2004 Mar;65(3):538-49.

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Drug Information