| Drug General Information |
| Drug ID |
D0Y7KE
|
| Former ID |
DNC007725
|
| Drug Name |
1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C26H29NO
|
| Canonical SMILES |
CCC1=CC=C(C=C1)C2(CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)O
|
| InChI |
1S/C26H29NO/c1-2-21-13-15-24(16-14-21)26(28)17-19-27(20-18-26)25(22-9-5-3-6-10-22)23-11-7-4-8-12-23/h3-16,25,28H,2,17-20H2,1H3
|
| InChIKey |
JHTQREMVHFRWEJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Mu-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Nociceptin receptor |
Target Info |
Inhibitor |
[1]
|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Neuroactive ligand-receptor interaction
|
|
Estrogen signaling pathway
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Morphine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Opioid prodynorphin pathway
|
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Pathway Interaction Database
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IL4-mediated signaling events
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Reactome
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Peptide ligand-binding receptors
|
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
|
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WikiPathways
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TCR Signaling Pathway
|
|
GPCRs, Class A Rhodopsin-like
|
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Peptide GPCRs
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Opioid Signalling
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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|
GPCR downstream signaling
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. |
|---|
