Drug Information

Drug General Information
Drug ID
D0Y7QZ
Former ID
DNC010638
Drug Name
4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530491]
Structure
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2D MOL

3D MOL
Formula
C20H16N4
Canonical SMILES
CC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=CC4=CC=CC=C4N=C3
InChI
1S/C20H16N4/c1-14-6-8-17(9-7-14)23-20-21-11-10-19(24-20)16-12-15-4-2-3-5-18(15)22-13-16/h2-13H,1H3,(H,21,23,24)
InChIKey
DLSCDFDGOMZHSD-UHFFFAOYSA-N
PubChem Compound ID
44820377
Target and Pathway
Target(s) G2/mitotic-specific cyclin B1 Target Info Inhibitor [530491]
Cell division control protein 2 homolog Target Info Inhibitor [530491]
KEGG Pathway FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
Progesterone-mediated oocyte maturationhsa04110:Cell cycle
Gap junction
Progesterone-mediated oocyte maturation
Herpes simplex infection
Epstein-Barr virus infection
Viral carcinogenesis
NetPath Pathway TCR Signaling PathwayNetPath_21:RANKL Signaling Pathway
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Validated targets of C-MYC transcriptional activation
PLK1 signaling events
FoxO family signaling
Direct p53 effectors
FOXM1 transcription factor network
C-MYB transcription factor networkp73pathway:p73 transcription factor network
E2F transcription factor network
AP-1 transcription factor network
Retinoic acid receptors-mediated signaling
Reactome Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Cyclin A/B1 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-110056:MAPK3 (ERK1) activation
E2F mediated regulation of DNA replication
G0 and Early G1
Cyclin B2 mediated events
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
G1/S-Specific Transcription
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways DNA Damage Response
G1 to S cell cycle control
Mitotic Prophase
Mitotic Prometaphase
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
AMPK SignalingWP707:DNA Damage Response
TGF beta Signaling Pathway
PPAR Alpha Pathway
MAP kinase activation in TLR cascade
RAF/MAP kinase cascade
BMI1
Spinal Cord Injury
Prostate Cancer
Regulation of Microtubule Cytoskeleton
Integrated Cancer pathway
References
Ref 530491Eur J Med Chem. 2010 Jan;45(1):379-86. Epub 2009 Oct 13.Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.
Ref 530491Eur J Med Chem. 2010 Jan;45(1):379-86. Epub 2009 Oct 13.Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.

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