Drug Information

Drug General Information
Drug ID
D0Y7TS
Former ID
DAP000635
Drug Name
Trimetrexate
Synonyms
TMQ; Trimetrexato; Trimetrexatum; JB 11; Jb-11; Trimetrexato [INN-Spanish]; Trimetrexatum [INN-Latin]; Trimetrexate (USAN/INN); Trimetrexate [USAN:BAN:INN]; 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline; 5-Methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine; 5-methyl-6-({[3,4,5-tris(methyloxy)phenyl]amino}methyl)quinazoline-2,4-diamine; 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine; 6-[((3,4,5-Trimethoxyphenyl)amino)methyl]-5-methyl-2,4-quinazolinediamine
Drug Type
Small molecular drug
Indication Toxoplasmosis; Pneumocystis carinii pneumonia [ICD10:B58] Approved [551871]
Therapeutic Class
Antifungal Agents
Company
Medimmune Oncology Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H23N5O3
InChI
InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
InChIKey
NOYPYLRCIDNJJB-UHFFFAOYSA-N
CAS Number
CAS 52128-35-5
PubChem Compound ID
5583
PubChem Substance ID
13336, 136953, 596038, 6646166, 7980836, 8153437, 12012739, 14803927, 26755046, 29224621, 46505247, 46518373, 47207896, 48416673, 50064855, 50110873, 53787691, 56435904, 57322856, 58106635, 78747684, 93166287, 96021815, 103181342, 104309650, 124892340, 124892341, 128733693, 134337925, 135000788, 137002678, 142433670, 160964491, 162973724, 164784678, 172916567, 179117157, 198941687, 223365948, 223366334, 223773875, 226396064
SuperDrug ATC ID
P01AX07
SuperDrug CAS ID
cas=052128355
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [535058], [538096]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535058Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Antimicrob Agents Chemother. 2000 Nov;44(11):3092-6.
Ref 538096Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. J Med Chem. 1998 Apr 23;41(9):1409-16.

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