Drug Information

Drug General Information
Drug ID
D0YA8J
Former ID
DIB019935
Drug Name
grayanotoxin III
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539697]
Structure
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2D MOL
Formula
C20H34O6
InChI
InChI=1S/C20H34O6/c1-16(2)13(21)7-12-18(4,25)11-6-5-10-15(23)19(11,9-17(10,3)24)8-14(22)20(12,16)26/h10-15,21-26H,5-9H2,1-4H3/t10-,11+,12+,13+,14-,15-,17-,18-,19+,20+/m1/s1
InChIKey
BWMFRQKICHXLSH-FIRPSQKQSA-N
PubChem Compound ID
11057730
PubChem Substance ID
16124660, 23271377, 50548762, 103580633, 119525858, 135652689, 198972044, 227262045
Target and Pathway
Target(s) Sodium channel protein type 4 subunit alpha Target Info Activator [526148]
Reactome Interaction between L1 and Ankyrins
References
Ref 539697(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2628).
Ref 526148Novel site on sodium channel alpha-subunit responsible for the differential sensitivity of grayanotoxin in skeletal and cardiac muscle. Mol Pharmacol. 2001 Oct;60(4):865-72.

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