Drug Information

Drug General Information
Drug ID
D0YF6L
Former ID
DIB001259
Drug Name
KST-5468
Synonyms
KST-5468; T-type calcium channel antagonist (pain); T-type calcium channel antagonist (pain), SNU/KIST
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [543872]
Company
Seoul National University
Structure
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2D MOL

3D MOL
Canonical SMILES
n1(nc(cc1CC(C)C)CNC(=O)CN1CCN(CC1)c1ccccc1)c1ccccc1
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Antagonist [543872]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart Contraction
Reactome NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growth
References
Ref 543872(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536).
Ref 543872(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536).

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