Drug General Information
Drug ID
D0YH0N
Former ID
DIB005117
Drug Name
Metadoxine
Synonyms
MG01CI; Metadoxine (oral sustained release, ADHD); Metadoxine (oral extended release, ADHD), Alcobra; Metadoxine (oral sustained release, ADHD), Alcobra
Drug Type
Small molecular drug
Indication Myeloma [ICD9: 203; ICD10:C90] Approved [524626], [531706]
Company
Alcobra
Structure
Download
2D MOL

3D MOL

Formula
C13H18N2O6
Canonical SMILES
c1(c(cnc(c1O)C)CO)CO.[C@H]1(CCC(=O)N1)C(=O)O
CAS Number
CAS 74536-44-0
PubChem Compound ID
Target and Pathway
Target(s) Sodium- and chloride-dependent GABA transporter 1 Target Info Modulator
KEGG Pathway GABAergic synapse
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
References
Ref 524626ClinicalTrials.gov (NCT02051842) Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis. U.S. National Institutes of Health.
Ref 531706Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease. Hum Psychopharmacol. 2011 Dec;26(8):554-9.

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