Drug General Information
Drug ID
D0YJ5H
Former ID
DIB001646
Drug Name
EX-1311
Synonyms
EX-1311; EX-1350; EX-1365; EX-1832; EX-51; Ghrelin antagonists (metabolic disease); Ghrelin antagonists (metabolic disease), Elixir; Ghrelin antagonists (metabolic disease), Elixir/Novartis
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Investigative [543633]
Company
Elixir Pharmaceuticals Inc
Structure
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2D MOL

3D MOL

Canonical SMILES
C(CCN(CC)CC)S(=O)(=O)N[C@H](CCc1ccccc1)c1[nH]nc(n1)c1cc<br />c(cc1)OC
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Antagonist [543633]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543633(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246).
Ref 543633(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246).

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