| Drug General Information |
| Drug ID |
D0YZ7H
|
| Former ID |
DNC005891
|
| Drug Name |
JNJ-10198409
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H16FN3O2
|
| InChI |
InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)
|
| InChIKey |
ZDNURMVOKAERHZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14752920, 14951134, 24107045, 26759343, 44833378, 75483471, 99302741, 103472640, 104064435, 125335339, 134343096, 139579683, 139579694, 162248056, 163123719, 163687510, 175607425, 178102642, 180391258, 196375753, 204362249, 224103797, 229136352, 243368940, 246434021, 252457960
|
| Target and Pathway |
| Target(s) |
Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Fyn tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[2]
|
| Proto-oncogene c-Abl |
Target Info |
Inhibitor |
[2]
|
| Lck tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| Alpha platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
MAPK signaling pathway
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|
Ras signaling pathway
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|
Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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PI3K-Akt signaling pathway
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Focal adhesion
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Gap junction
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Regulation of actin cytoskeleton
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HTLV-I infection
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Pathways in cancer
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MicroRNAs in cancer
|
|
Glioma
|
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Prostate cancer
|
|
Melanoma
|
|
Central carbon metabolism in cancer
|
|
Choline metabolism in cancerhsa04071:Sphingolipid signaling pathway
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|
Axon guidance
|
|
Osteoclast differentiation
|
|
Adherens junction
|
|
Platelet activation
|
|
Natural killer cell mediated cytotoxicity
|
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Cholinergic synapse
|
|
Prion diseases
|
|
Pathogenic Escherichia coli infection
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|
Measles
|
|
Viral myocarditishsa04012:ErbB signaling pathway
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Chemokine signaling pathway
|
|
Endocytosis
|
|
VEGF signaling pathway
|
|
Tight junction
|
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GABAergic synapse
|
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
|
|
Estrogen signaling pathway
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Prolactin signaling pathway
|
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Thyroid hormone signaling pathway
|
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Oxytocin signaling pathway
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Tuberculosis
|
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Hepatitis B
|
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Viral carcinogenesis
|
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Proteoglycans in cancerhsa04012:ErbB signaling pathway
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Cell cycle
|
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Neurotrophin signaling pathway
|
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Chronic myeloid leukemia
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Viral myocarditishsa04064:NF-kappa B signaling pathway
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Primary immunodeficiencyhsa04010:MAPK signaling pathway
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Choline metabolism in cancer
|
|
NetPath Pathway
|
TSH Signaling Pathway
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IL2 Signaling Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
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IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Angiogenesis
|
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PDGF signaling pathwayP00007:Axon guidance mediated by semaphorins
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Cadherin signaling pathway
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Integrin signalling pathway
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Parkinson diseaseP00005:Angiogenesis
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Parkinson disease
|
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CCKR signaling map STP00008:Axon guidance mediated by Slit/RoboP00049:Parkinson disease
|
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T cell activationP00005:Angiogenesis
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|
PDGF signaling pathway
|
|
Pathway Interaction Database
|
Signaling events mediated by PTP1B
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Beta3 integrin cell surface interactions
|
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S1P3 pathway
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Nectin adhesion pathway
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Signaling events mediated by TCPTP
|
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SHP2 signaling
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S1P1 pathway
|
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
|
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PDGF receptor signaling networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
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ErbB4 signaling events
|
|
Glypican 1 network
|
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TCR signaling in naï
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Ephrin A reverse signaling
|
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Reelin signaling pathway
|
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Regulation of p38-alpha and p38-beta
|
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TCR signaling in naï
|
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
|
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Netrin-mediated signaling events
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IL2-mediated signaling events
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CXCR4-mediated signaling events
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Class I PI3K signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
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amb2 Integrin signaling
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EPHA forward signaling
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E-cadherin signaling in keratinocytes
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Nephrin/Neph1 signaling in the kidney podocyte
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Signaling events mediated by VEGFR1 and VEGFR2
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Syndecan-3-mediated signaling events
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Ephrin B reverse signaling
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Alpha-synuclein signaling
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Signaling events mediated by focal adhesion kinaseendothelinpathway:Endothelins
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Signaling events mediated by PRL
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LPA receptor mediated events
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Atypical NF-kappaB pathway
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Plasma membrane estrogen receptor signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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EPHB forward signaling
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CDC42 signaling events
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Signaling events regulated by Ret tyrosine kinase
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Arf6 signaling events
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FAS (CD95) signaling pathway
|
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Alpha9 beta1 integrin signaling events
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EGF receptor (ErbB1) signaling pathway
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Regulation of Androgen receptor activity
|
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E-cadherin signaling in the nascent adherens junction
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Integrins in angiogenesis
|
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ErbB1 downstream signaling
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ErbB2/ErbB3 signaling events
|
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Nongenotropic Androgen signaling
|
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Internalization of ErbB1
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CXCR3-mediated signaling events
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Syndecan-2-mediated signaling events
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Class I PI3K signaling events mediated by Akt
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Trk receptor signaling mediated by PI3K and PLC-gamma
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EPHA2 forward signaling
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FGF signaling pathway
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Alpha4 beta1 integrin signaling events
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Signaling events mediated by focal adhesion kinasep73pathway:p73 transcription factor network
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ATM pathway
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Regulation of Telomerase
|
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Lissencephaly gene (LIS1) in neuronal migration and development
|
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Neurotrophic factor-mediated Trk receptor signaling
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Validated transcriptional targets of TAp63 isoforms
|
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p53 pathway
|
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Regulation of retinoblastoma proteinnfkappabatypicalpathway:Atypical NF-kappaB pathway
|
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IL12-mediated signaling events
|
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IL2 signaling events mediated by PI3K
|
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IL2 signaling events mediated by STAT5
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Alpha-synuclein signalingatf2_pathway:ATF-2 transcription factor network
|
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PDGFR-alpha signaling pathway
|
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PDGF receptor signaling network
|
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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PIP3 activates AKT signaling
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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RAF/MAP kinase cascadeR-HSA-114604:GPVI-mediated activation cascade
|
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Regulation of KIT signaling
|
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Cell surface interactions at the vascular wall
|
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FCGR activation
|
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PECAM1 interactions
|
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DAP12 signaling
|
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EPH-Ephrin signaling
|
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Role of LAT2/NTAL/LAB on calcium mobilization
|
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Nephrin interactions
|
|
NCAM signaling for neurite out-growth
|
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CD28 co-stimulation
|
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CD28 dependent PI3K/Akt signaling
|
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CD28 dependent Vav1 pathway
|
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CTLA4 inhibitory signaling
|
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EPHB-mediated forward signaling
|
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EPHA-mediated growth cone collapse
|
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EPH-ephrin mediated repulsion of cells
|
|
CRMPs in Sema3A signaling
|
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DCC mediated attractive signaling
|
|
Netrin mediated repulsion signals
|
|
VEGFA-VEGFR2 Pathway
|
|
Dectin-2 family
|
|
CD209 (DC-SIGN) signaling
|
|
RAF/MAP kinase cascade
|
|
Platelet Adhesion to exposed collagen
|
|
Regulation of signaling by CBL
|
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation
|
|
CDO in myogenesis
|
|
RHO GTPases Activate WASPs and WAVEs
|
|
HDR through Single Strand Annealing (SSA)
|
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
|
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Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
|
|
Phosphorylation of CD3 and TCR zeta chains
|
|
Translocation of ZAP-70 to Immunological synapse
|
|
Generation of second messenger molecules
|
|
PD-1 signaling
|
|
Interleukin-2 signalingR-HSA-1257604:PIP3 activates AKT signaling
|
|
WikiPathways
|
Regulation of Actin Cytoskeleton
|
|
MAPK Signaling Pathway
|
|
Osteoblast Signaling
|
|
Focal Adhesion
|
|
PIP3 activates AKT signaling
|
|
PDGF Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Signaling by PDGFWP69:TCR Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
IL-2 Signaling Pathway
|
|
Kit receptor signaling pathway
|
|
IL-3 Signaling Pathway
|
|
Ectoderm Differentiation
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Signaling by the B Cell Receptor (BCR)
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Pathogenic Escherichia coli infection
|
|
TSLP Signaling Pathway
|
|
IL-7 Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
Platelet Adhesion to exposed collagen
|
|
Netrin-1 signaling
|
|
Nephrin interactions
|
|
NCAM signaling for neurite out-growth
|
|
Integrin-mediated Cell Adhesion
|
|
GPVI-mediated activation cascade
|
|
Costimulation by the CD28 family
|
|
Cell surface interactions at the vascular wallWP673:ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Pregnane X Receptor pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Polycystic Kidney Disease Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
AGE/RAGE pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Angiogenesis
|
|
Androgen receptor signaling pathwayWP2864:Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
Fcgamma receptor (FCGR) dependent phagocytosis
|
|
ATM Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Integrated Breast Cancer Pathway
|
|
Signaling by Robo receptor
|
|
Myogenesis
|
|
Factors involved in megakaryocyte development and platelet productionWP61:Notch Signaling Pathway
|
|
Inflammatory Response Pathway
|
|
TCR signaling
|
|
Costimulation by the CD28 familyWP51:Regulation of Actin Cytoskeleton
|
|
Hair Follicle Development: Organogenesis (Part 2 of 3)
|
|
Cardiac Progenitor Differentiation
|
|
Allograft Rejection
|
|
Signaling by PDGF
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6020). |
|---|
| REF 2 | J Med Chem. 2005 Dec 29;48(26):8163-73.(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. |
|---|
