Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Z0PB
|
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| Former ID |
DCL000178
|
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| Drug Name |
NGD-8243
|
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| Drug Type |
Small molecular drug
|
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| Indication | Acute or chronic pain [ICD9: 338,780; ICD10:R52, G89] | Discontinued in Phase 2 | [1] | ||
| Therapeutic Class |
Analgesics
|
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| Company |
Neurogen Corp
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H12F6N4
|
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| Canonical SMILES |
C1=CC(=CC=C1C(F)(F)F)NC2=NC=NC3=C2C=CC(=C3)C4=C(C=CN=C4<br />)C(F)(F)F
|
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| InChI |
1S/C21H12F6N4/c22-20(23,24)13-2-4-14(5-3-13)31-19-15-6-1-12(9-18(15)29-11-30-19)16-10-28-8-7-17(16)21(25,26)27/h1-11H,(H,29,30,31)
|
||||
| InChIKey |
LJYSWMNKRHYTHY-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Vanilloid receptor 1 | Target Info | Blocker | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023970) | ||||
| REF 2 | Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5. | ||||
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