Drug Information

Drug General Information
Drug ID
D0Z1HQ
Former ID
DNC001138
Drug Name
PNU156804
Drug Type
Small molecular drug
Indication Renal transplantation [ICD9: 279.5; ICD10:D89.8] Terminated [546472]
Structure
Download
2D MOL

3D MOL
Formula
C16H29N3O6S
Canonical SMILES
CCCCCCSCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
InChI
1S/C16H29N3O6S/c1-2-3-4-5-8-26-10-12(15(23)18-9-14(21)22)19-13(20)7-6-11(17)16(24)25/h11-12H,2-10,17H2,1H3,(H,18,23)(H,19,20)(H,21,22)(H,24,25)/t11-,12-/m0/s1
InChIKey
HXJDWCWJDCOHDG-RYUDHWBXSA-N
CAS Number
CAS 24853-32-5
PubChem Compound ID
97536
PubChem Substance ID
5817, 585425, 819236, 821129, 823936, 824020, 824024, 826418, 829518, 829659, 830064, 834684, 835651, 836634, 6436227, 8022091, 8028121, 10229013, 10317448, 11538282, 17422866, 22394985, 24398011, 26703322, 26706156, 26736639, 44427844, 46393646, 46393976, 46488157, 50064611, 50130551, 53786802, 57336490, 57580714, 79069274, 85261598, 85261599, 85852805, 87226151, 87544252, 103398048, 103827809, 103993604, 104421164, 124361029, 128126732, 134340373, 134340524, 135052467
Target and Pathway
Target(s) Tyrosine-protein kinase JAK3 Target Info Inhibitor [535337]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Measles
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Primary immunodeficiency
PANTHER Pathway Interleukin signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
Pathway Interaction Database IL4-mediated signaling events
CD40/CD40L signaling
Signaling events mediated by TCPTP
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Reactome GPVI-mediated activation cascade
Interleukin-7 signaling
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
IL-4 Signaling Pathway
Interleukin-2 signaling
Interleukin-7 signaling
Oncostatin M Signaling Pathway
IL-9 Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 546472Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008393)
Ref 535337Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood. 2002 Jan 15;99(2):680-9.

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