Drug Information

Drug General Information
Drug ID
D0Z4KX
Former ID
DCL000801
Drug Name
Farampator
Synonyms
CX 691; CX-691; Farampator (USAN/INN); 1-(Benzofurazan-5-ylcarbonyl)piperidine; 2,1,3-benzoxadiazol-5-yl(piperidin-1-yl)methanone
Drug Type
Small molecular drug
Indication Major depressive disorder; Schizophrenia [ICD9: 296.2, 296.3, 710.0, 295; ICD10:F32, F33, M32, F20] Discontinued in Phase 1 [547029]
Company
Cortex Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C12H13N3O2
Canonical SMILES
C1CCN(CC1)C(=O)C2=CC3=NON=C3C=C2
InChI
1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2
InChIKey
XFVRBYKKGGDPAJ-UHFFFAOYSA-N
CAS Number
CAS 211735-76-1
PubChem Compound ID
4118151
PubChem Substance ID
6046381, 8354027, 14773821, 35375401, 47206078, 47895538, 57304383, 57356757, 77549801, 112659749, 123086562, 123109527, 129682877, 134339280, 135203122, 137006435, 139458671, 140528391, 198944660, 223765608, 226972323
Target and Pathway
Target(s) Glutamate receptor 1 Target Info Binder [536463]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Dopaminergic synapse
Long-term depression
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Nicotine addiction
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Pathway Interaction Database EPHB forward signaling
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ER
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Amyotrophic lateral sclerosis (ALS)
BDNF signaling pathway
References
Ref 547029Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012259)
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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