Drug General Information |
Drug ID |
D0Z4RC
|
Former ID |
DNCL002259
|
Drug Name |
CUDC-101
|
Drug Type |
Small molecular drug
|
Indication |
Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]
|
Phase 1 |
[1]
|
Company |
Curis
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C24H26N4O4
|
Canonical SMILES |
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)N<br />O
|
InChI |
1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
|
InChIKey |
PLIVFNIUGLLCEK-UHFFFAOYSA-N
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PubChem Compound ID |
|
PubChem Substance ID |
49660356, 56171066, 99437021, 103729562, 104162129, 124757071, 125163875, 131480726, 136340142, 136367359, 136920313, 137276021, 137618464, 143499549, 144115857, 152237699, 152258136, 152344190, 160646975, 162037496, 162202705, 163643062, 164045128, 164193971, 164838612, 174525778, 180414608, 185998813, 188899559, 198955528, 216125612, 223381965, 223704773, 226471483, 248177722, 252215203, 252451419
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Target and Pathway |
Target(s) |
Epidermal growth factor receptor |
Target Info |
Modulator |
[1]
|
Receptor protein-tyrosine kinase erbB-2 |
Target Info |
Modulator |
[1]
|
KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
|
Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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HIF-1 signaling pathway
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FoxO signaling pathway
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Endocytosis
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PI3K-Akt signaling pathway
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Dorso-ventral axis formation
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Focal adhesion
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Adherens junction
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Gap junction
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Oxytocin signaling pathway
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Epithelial cell signaling in Helicobacter pylori infection
|
Hepatitis C
|
Pathways in cancer
|
Proteoglycans in cancer
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MicroRNAs in cancer
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Pancreatic cancer
|
Endometrial cancer
|
Glioma
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Prostate cancer
|
Melanoma
|
Bladder cancer
|
Non-small cell lung cancer
|
Central carbon metabolism in cancer
|
Choline metabolism in cancerhsa04012:ErbB signaling pathway
|
NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
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Cadherin signaling pathway
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EGF receptor signaling pathwayP00012:Cadherin signaling pathway
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EGF receptor signaling pathway
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Pathway Interaction Database
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LPA receptor mediated events
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Signaling events mediated by PTP1B
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Arf6 signaling events
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Signaling events mediated by TCPTP
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Thromboxane A2 receptor signaling
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SHP2 signaling
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Regulation of Telomerase
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EGF receptor (ErbB1) signaling pathway
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EGFR-dependent Endothelin signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
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Direct p53 effectors
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ErbB1 downstream signaling
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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E-cadherin signaling in keratinocytes
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ErbB receptor signaling network
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Internalization of ErbB1
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Stabilization and expansion of the E-cadherin adherens junction
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a6b1 and a6b4 Integrin signaling
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Syndecan-3-mediated signaling eventserbb4_pathway:ErbB4 signaling events
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ErbB2/ErbB3 signaling events
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Validated targets of C-MYC transcriptional repression
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PathWhiz Pathway
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Phosphatidylinositol Phosphate Metabolism
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Reactome
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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
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SHC1 events in ERBB2 signaling
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PLCG1 events in ERBB2 signaling
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PIP3 activates AKT signaling
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GRB2 events in EGFR signaling
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GAB1 signalosome
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SHC1 events in EGFR signaling
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EGFR downregulation
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GRB2 events in ERBB2 signaling
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PI3K events in ERBB2 signaling
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EGFR Transactivation by Gastrin
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Constitutive Signaling by Aberrant PI3K in Cancer
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Constitutive Signaling by EGFRvIII
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RAF/MAP kinase cascadeR-HSA-1250196:SHC1 events in ERBB2 signaling
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Sema4D induced cell migration and growth-cone collapse
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RAF/MAP kinase cascade
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WikiPathways
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ErbB Signaling Pathway
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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MAPK Signaling Pathway
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Focal Adhesion
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Aryl Hydrocarbon Receptor Pathway
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Extracellular vesicle-mediated signaling in recipient cells
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TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
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Bladder Cancer
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Hair Follicle Development: Induction (Part 1 of 3)
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Signaling by ERBB4
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Signaling by ERBB2
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Gastrin-CREB signalling pathway via PKC and MAPK
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PIP3 activates AKT signaling
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Nanoparticle-mediated activation of receptor signaling
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Aryl Hydrocarbon Receptor
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Gastric cancer network 2
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AGE/RAGE pathway
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Signaling Pathways in Glioblastoma
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Arylhydrocarbon receptor (AhR) signaling pathway
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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Integrated Breast Cancer Pathway
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Signaling by EGFR
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L1CAM interactionsWP710:DNA Damage Response (only ATM dependent)
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Leptin signaling pathway
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Semaphorin interactions
|
References |
REF 1 | A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2015 Apr 1;21(7):1566-73. |