Drug General Information
Drug ID
D0Z5HR
Former ID
DIB009120
Drug Name
VX-661
Synonyms
CFTR correctors (cystic fibrosis), Vertex; Cystic fibrosis transmembrane regulator corrector (cystic fibrosis), Vertex
Drug Type
Small molecular drug
Indication Cystic fibrosis [ICD9: 277; ICD10:E84] Phase 2 [525275]
Company
Vertex Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL

Formula
C26H27F3N2O6
Canonical SMILES
CC(C)(CO)C1=CC2=CC(=C(C=C2N1CC(CO)O)F)NC(=O)C3(CC3)C4=C<br />C5=C(C=C4)OC(O5)(F)F
InChI
1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1
InChIKey
MJUVRTYWUMPBTR-MRXNPFEDSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) cystic fibrosis transmembrane conductance regulator Target Info Regulator [532904]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 525275ClinicalTrials.gov (NCT02508207) A Phase 2 Study to Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation.
Ref 532904CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11.

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