Drug Information

Drug General Information
Drug ID
D0Z5QA
Former ID
DIB018470
Drug Name
12S-HETE
Synonyms
12(S)-hydroxyeicosatetraenoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540351]
Structure
Download
2D MOL
Formula
C20H32O3
InChI
InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1
InChIKey
ZNHVWPKMFKADKW-LQWMCKPYSA-N
PubChem Compound ID
5283155
PubChem Substance ID
4266113, 7978570, 11038789, 14718419, 15024710, 17395775, 24895806, 26754745, 26754746, 39316569, 47810477, 48184717, 50110767, 77183168, 92309715, 99300629, 99302147, 104046388, 113859250, 135651372, 142970220, 162219524, 164789678, 178102154, 179205502, 227471497, 241094904, 242324953, 252455439, 252463834
Target and Pathway
Target(s) GPR31 Target Info Agonist [531535]
Leukotriene B4 receptor 2 Target Info Agonist [526017]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540351(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3404).
Ref 526017Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. Epub 2001 Jan 18.
Ref 531535Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. J Biol Chem. 2011 Sep 30;286(39):33832-40.

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