Drug Information

Drug General Information
Drug ID
D0Z9RJ
Former ID
DNCL001764
Drug Name
GS 9667
Drug Type
Small molecular drug
Indication Hypertriglyceridemia [ICD9: 272.1, 427; ICD10:E78.1, E78.2, E78.3, I47-I49] Phase 1 [540961], [547637]
Company
Gilead Sciences
Structure
Download
2D MOL
Formula
C21H24FN5O4S
InChI
InChI=1S/C21H24FN5O4S/c22-11-4-1-2-7-15(11)32-8-14-17(29)18(30)21(31-14)27-10-25-16-19(23-9-24-20(16)27)26-12-5-3-6-13(12)28/h1-2,4,7,9-10,12-14,17-18,21,28-30H,3,5-6,8H2,(H,23,24,26)/t12-,13-,14-,17-,18-,21-/m1/s1
InChIKey
IZRXENCTXNMAMI-DIJFLQFKSA-N
PubChem Compound ID
11561692
PubChem Substance ID
16663905, 23681347, 42703583, 74636002, 138287523, 163642486, 178102228, 198951765, 227388523, 245011856
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Agonist [532240]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540961(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5593).
Ref 547637Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018030)
Ref 532240Reduction of free fatty acids, safety, and pharmacokinetics of oral GS-9667, an A(1) adenosine receptor partial agonist. J Clin Pharmacol. 2013 Apr;53(4):385-92.

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